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Research Interest:
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I am interested in the early diagnosis of cancer, particularly focusing on lung cancer, ovarian cancer, and esophagus cancer. I am also working on DNA, protein microarray and proteomics, bioinformatics, cell and gene engineering, and biomedicine.
I am the member of the American Physiological Society, the American Association for the Advancement of Science, and American Association for Cancer Research. I am also the referee of Cancer Detection and Prevention, Cellular and Molecular Biology, Biological Procure Online, Vascular Pharmacology, and Pharmacology Research etc.
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Recent Research Projects:
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(1)
Development of protein microarray for early detection and diagnosis of esophagus cancer (PI), 2006-2008
Funded by: Hebei Province
Amount: RMB 50,000 |
(2)
Rapid determination of animal food safety and the development of protein microarray for early detection and diagnosis of lung cancer (PI), 2005-2007
Funded by: Hebei Province, Ministry of Science and Technology
Amount: RMB 300,000 |
(3)
Study on protein microarray in early diagnosis of non-small cell lung cancer (PI), 2005-2007
Funded by: Science and Technology Bureau of Baoding, Hebei
Amount: RMB 100,000 |
(4)
Cancer Research and Protection , 2004
Funded by: Cancer Research and Protection Fund & American Lung Association, USA |
(5)
VA Research Fund , 2003
Funded by: VA Research Fund, USA |
(6)
Cancer research , 2003
Funded by: Department of Health and Human Services, USA |
(7)
Lung Cancer Research , 2002
Funded by: Kentucky Lung Cancer Research Fund, USA |
(8)
Lung research , 2001
Funded by: Research Fund, American Lung Association, USA |
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Selected Publications:
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(1)
L Zhong*, S Coe, AJ Stromberg, NH Khattar, JR Jett, EA Hirschowitz. Profiling Tumor-associated Autoantibodies for Early Stage Non-Small Cell Lung Cancer. 2006 The Journal of Thoracic Oncology
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(2)
L Zhong*, Heat shock proteins in lung cancer. Clinica Chimica Acta 2006 (Invited review, Manuscript
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(3)
L Zhong*, GE Hidalgo, AJ Stromberg, NH Khattar, JR Jett, EA Hirschowitz. Protein Microarray as a Diagnostic Assay for Non-Small Cell Lung Cancer. American Journal of Respiratory and Critical Care Medicine. 2005 Nov 15;172(10):1308-1314
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(4)
L Zhong*, XJ Peng, AJ Stromberg, GE Hidalgo, DE Doherty and EA Hirschowitz. Identification of Autoabtibodies and Tumor-Associate Proteins in Serum of Non-Small Cell Lung Cancer Patients. Proteomics. 2004 (4):1216-1225
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(5)
Zhong L, Peng X, Hidalgo GE, Doherty DE, Stromberg AS, Hirschowitz EA. Efficient identification and use of tumor-associated antibodies as markers of non-small cell lung cancer. Chest. 2004 May;125(5 Suppl):105S-106S
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(6)
Li Zhong, Perry Kannan and Michael Tainsky. Characterization of the Interaction of the Positive Coactivator PC4 with AP-2alpha. Gene 2003 Nov 27;320:155-164
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(7)
L Zhong*, GE Hidalgo, DE Doherty and EA Hirschowitz. Autoantibodies to Heat Shock Proteins 70 and 90 in Serum of Non-Small-Cell Lung Cancer Patients. Cancer Detection and Prevention, 2003;27(4):285-290
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(8)
GE Hidalgo, L Zhong, DE Doherty and EA Hirschowitz. Plasma PGE-2 Levels and Altered Cytokine Profiles in Adherent Peripheral Blood Mononuclear Cells in Non-Small Cell Lung Cancer. Molecular Cancer 1:5, 2002
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(9)
JA Schwartz, L Zhong, SD Collins and DF Skafar. Mutations Targeted to a Predicted Helix in the Extreme Carboxyl-terminal Region of the Human Estrogen Receptor-alpha Alter Its Response to Estradiol and 4-Hydroxytamoxifen. J. Biol. Chem. 277(15):1320-1329; Apr 12,2002
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(10)
Li Zhong and Debra. F. Skafar. Mutations of Tyrosine 537 in the Human Estrogen Receptor alpha Selectively Alter the Receptor's Affinity for Estradiol and the Kinetics of the Interaction. Biochemistry. 41(13):4209-4217,2002
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(11)
MR. Yudt, Vorojeikina D, L Zhong, DF Skafar and AC Notides, Function of the Human Estrogen Receptor Tyrosine 537 in Hormone Binding, DNA bind, and Transactivation. Biochemistry, 38(43): 14146-14156, October, 1999
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(12)
Maas JL, Zhong L, Galletta GJ. In vitro screening of strawberry plant and root cultures for resistance to Phytophthora Fragariae and P. Cacatorum. Acta Horticulture 348: 496-499, 1993
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Copyright 2006